Table 1.
10 best bottle neck scores of seed and connector proteins. The selection was done on the basis of higher bottle neck score and clustering coefficient (less than 0.5, these proteins were considered as a date hub proteins).
| S. No | Name | Bottle neck | Betweenness | Closeness | Clustering coefficient | Degree |
|---|---|---|---|---|---|---|
| 1 | CREBBP | 52 | 13,223.35 | 155.8333 | 0.15837 | 50 |
| 2 | TP53 | 22 | 7,640.317 | 148.4167 | 0.17639 | 38 |
| 3 | RELA | 14 | 4,458.032 | 149.0833 | 0.20863 | 51 |
| 4 | MAPK1 | 13 | 4,779.75 | 146.5 | 0.18316 | 47 |
| 5 | NFKB1 | 11 | 3,211.738 | 144.8333 | 0.22304 | 44 |
| 6 | CYP1A1 | 10 | 4,831.488 | 110.8667 | 0.43137 | 18 |
| 7 | SRC | 9 | 2,899.138 | 135.6667 | 0.17424 | 33 |
| BRCA1 | 9 | 1537.711 | 128.1 | 0.38413 | 36 | |
| EDN1 | 9 | 684.0157 | 123.8333 | 0.29412 | 18 | |
| ATR | 9 | 647.5952 | 124.0667 | 0.38391 | 30 | |
| 8 | RB1 | 7 | 2,625.42 | 142.8333 | 0.29445 | 38 |
| SP1 | 7 | 391.5314 | 130.6667 | 0.34762 | 21 | |
| 9 | CASP8 | 6 | 2,299.261 | 123.3667 | 0.4152 | 19 |
| STAT1 | 6 | 1,012.291 | 130.1667 | 0.36594 | 24 | |
| CREB1 | 6 | 597.4255 | 121.6667 | 0.30882 | 17 | |
| 10 | AKT1 | 5 | 2,328.794 | 137.4167 | 0.17094 | 27 |
| IL8 | 5 | 2,227.319 | 121.1667 | 0.4058 | 24 | |
| CDH1 | 5 | 1,162.138 | 113 | 0.34848 | 12 | |
| KRAS | 5 | 917.6512 | 120.8333 | 0.25692 | 23 | |
| SYK | 5 | 796.2624 | 123.6667 | 0.24265 | 17 | |
| CCR5 | 5 | 669.6932 | 108.3667 | 0.42222 | 10 | |
| HDAC3 | 5 | 471.1578 | 124.3333 | 0.35263 | 20 |