Table 3.
Multivariable Poisson models predicting effects of three randomized supplement interventions on working memory*
| Cohort | Model 1† | Model 2‡ | Model 1§ | Model 2¶ | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Adjusted rate ratio (95% CI) | P value | Adjusted rate ratio (95% CI) | P value | Adjusted rate ratio (95% CI) | P value | Adjusted rate ratio (95% CI) | P value | ||||
| Children younger than 4 | |||||||||||
| Intention-to-treat cohort | |||||||||||
| NEWSUP v control | 1.16 (1.02 to 1.32) | 0.03 | 1.20 (1.02 to 1.41) | 0.03 | 1.16 (1.02 to 1.32) | 0.03 | 1.20 (1.02 to 1.41) | 0.03 | |||
| FBF v control | 1.09 (0.93 to 1.27) | 0.30 | 1.09 (0.91 to 1.32) | 0.35 | 1.08 (0.92 to 1.27) | 0.33 | 1.08 (0.89 to 1.32) | 0.41 | |||
| NEWSUP v FBF | 1.06 (0.93 to 1.22) | 0.35 | 1.10 (0.93 to 1.29) | 0.28 | 1.07 (0.93 to 1.23) | 0.34 | 1.11 (0.93 to 1.31) | 0.24 | |||
| Per protocol cohort | |||||||||||
| NEWSUP v control | 1.18 (1.03 to 1.35) | 0.02 | 1.25 (1.06 to 1.47) | 0.009 | 1.18 (1.03 to 1.35) | 0.02 | 1.25 (1.06 to 1.47) | 0.007 | |||
| FBF v control | 1.07 (0.90 to 1.26) | 0.44 | 1.06 (0.87 to 1.30) | 0.56 | 1.06 (0.90 to 1.26) | 0.50 | 1.05 (0.86 to 1.29) | 0.65 | |||
| NEWSUP v FBF | 1.10 (0.96 to 1.27) | 0.17 | 1.17 (0.99 to 1.39) | 0.06 | 1.11 (0.96 to 1.29) | 0.16 | 1.19 (1.00 to 1.42) | 0.05 | |||
| Children aged 4 and older | |||||||||||
| Intention-to-treat cohort | |||||||||||
| NEWSUP v control | 1.03 (0.97 to 1.10) | 0.31 | 1.02 (0.95 to 1.10) | 0.58 | 1.03 (0.96 to 1.09) | 0.43 | 1.02 (0.94 to 1.10) | 0.70 | |||
| FBF v control | 1.07 (1.01 to 1.13) | 0.02 | 1.07 (0.99 to 1.14) | 0.08 | 1.05 (0.99 to 1.12) | 0.08 | 1.05 (0.98 to 1.14) | 0.18 | |||
| NEWSUP v FBF | 0.97 (0.92 to 1.02) | 0.20 | 0.96 (0.90 to 1.02) | 0.21 | 0.97 (0.92 to 1.03) | 0.32 | 0.96 (0.90 to 1.03) | 0.30 | |||
| Per protocol cohort | |||||||||||
| NEWSUP v control | 1.03 (0.96 to 1.10) | 0.41 | 1.02 (0.94 to 1.11) | 0.63 | 1.02 (0.95 to 1.10) | 0.50 | 1.02 (0.93 to 1.11) | 0.66 | |||
| FBF v control | 1.07 (1.00 to 1.13) | 0.05 | 1.08 (0.99 to 1.16) | 0.07 | 1.05 (0.99 to 1.12) | 0.13 | 1.07 (0.98 to 1.16) | 0.12 | |||
| NEWSUP v FBF | 0.97 (0.91 to 1.02) | 0.24 | 0.95 (0.88 to 1.02) | 0.16 | 0.97 (0.92 to 1.03) | 0.38 | 0.96 (0.89 to 1.03) | 0.24 | |||
FBF=fortified blended food; NEWSUP=new supplement.
Number of stickers found in the spin the pots working memory test.
Model 1: calculated by a Poisson regression model accounting for clustering of children within families, adjusted for age, sex, study cohort, and baseline cognitive function. The natural logarithm of the total number of searches given is included as an offset.
Model 2: calculated by a Poisson regression model accounting for clustering of children within families, adjusted for age, sex, study cohort, baseline cognitive function, baseline weight for age (z score), baseline hemoglobin concentration (g/dL), change in weight for age (z score), and change in hemoglobin (g/dL). The natural logarithm of the total number of searches given is included as an offset.
Model 1 (excludes children with severe anemia at baseline): calculated by a Poisson regression model accounting for clustering of children within families, adjusted for age, sex, study cohort, and baseline cognitive function. The natural logarithm of the total number of searches given is included as an offset.
Model 2 (excludes children with severe anemia at baseline): calculated by a Poisson regression model accounting for clustering of children within families, adjusted for age, sex, study cohort, baseline cognitive function, baseline weight for age (z score), baseline hemoglobin concentration (g/dL), change in weight for age (z score), and change in hemoglobin (g/dL). The natural logarithm of the total number of searches given is included as an offset.