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. 2020 Jul 22;13:103. doi: 10.1186/s13041-020-00642-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Inflammatory responses in the injured cortex and striatum. a Sections from the cortex and striatum were immunostained for Iba-1 at the indicated times post injection. Photographs of the most damaged sections are shown. Arrows, Iba-1-positive cells with a hypertrophic morphology; arrowheads, Iba-1–positive cells at the boundary of injury sites. b At the indicated times after ATP injection, IL-1β, IL-6, and TNF-α mRNA levels were analyzed using RT-qPCR. Values are means ± SEMs of 5 animals for both cortex and striatum (*, p < 0.05; ***, p < 0.001; ns, not significant; two-way ANOVA, IL-1β: F(7, 56) = 14.03, p < 0.0001, interaction; F(2.091, 16.73) = 39.77, p < 0.0001, time; F (1, 8)=15.52, p = 0.0043, region; F(8, 56) = 0.964, p = 0.4731, subjects; IL-6: F(7, 56) = 6.29, p < 0.0001, interaction; F(2.031, 16.10) = 17.41, p < 0.0001, time; F (1, 8)=0.2387, p = 0.6383, region; F(8, 56) = 1.515, p = 0.1728, subjects; TNF-a: F(7, 56) = 1.842, p = 0.0972, interaction; F(2.772, 22.17) = 12.03, p < 0.0001, time; F (1, 8)=3.876, p = 0.0845, region; F(8, 56) = 0.7877, p = 0.6154, subjects)