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. 2020 Jul 22;13:103. doi: 10.1186/s13041-020-00642-0

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Time-dependent behavior of CD45-positive cells in the ATP-injured cortex and striatum. a Sections were obtained from the cortex and striatum at the indicated times post-ATP injection, and stained for CD45. CD45-positive cells were not detected in the intact brain, but appeared at the boundary of injury sites 1 d post-injury (arrows), and gradually filled the injury core at 3–30 d (arrows). Like Iba-1–positive cells, CD45-positive cells were more densely packed in areas surrounding the damage sites, and near the corpus callosum in the damaged cortex and striatum. b CD45 and MMP-13 mRNA levels were analyzed by RT-qPCR at the indicated times after ATP injection. Values are means ± SEMs of at least 3 animals (*, p < 0.05, **, p < 0.001; two-way ANOVA, CD45: F(4, 40) = 7.336, p = 0.0002, interaction; F(1.949, 19.49) = 19.87, p < 0.0001, time; F (1, 10)=26.01, p = 0.0005, region; F(10, 40) = 1.046, p = 0.4245, subjects; MMP-13: F (4, 32)=18.23, p < 0.0001, interaction; F(1.044, 8.349) = 57.95, p < 0.0001, time; F (1, 8)=16.19, p = 0.0038, region; F (8, 32)=1.489, p = 0.2002, subjects)