Fig. 5.

iMSC-sEV activate STAT3 signaling pathway in vivo and in vitro. a, b Western blotting analysis showing the expression level of p-STAT3 and STAT3 in the ipsilateral infarct brain 24 h after MCAO or sham operation. N = 3–5 per group. c, d HUVECs were cultured in OGD condition for 8 h, followed by normoxia condition with the treatment of iMSC-sEV or vehicle for another 24 h. Western blotting analysis was performed to evaluate the expression of p-STAT3 and STAT3 in HUVECs in indicated groups. N = 3 per group. Data are presented as mean ± SD. *P < 0.05