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. 2020 Jul 22;11:309. doi: 10.1186/s13287-020-01822-4

Fig. 6.

Fig. 6

Application of USC-organoids in renal function and drug screening. a GGT activity measurement for renal function and drug screening in 3D organoids. Percentage decrease in the absorbance: USC-organoids (aspirin 38.2%, penicillin G 63.0%, cisplatin 84.6%), USC-organoids with kECM (aspirin 42.8%, penicillin G 63.1%, cisplatin 86.8%), renal organoid (aspirin 38.8%, penicillin G 60.4%, cisplatin 86.4%) (five replicated samples for each group, data presented as mean ± SD). b Dose-response curves of cisplatin in in 3D organoids. The IC50 of cisplatin in USC-organoids, USC-organoids with kECM, and renal organoids were 0.778 mM, 1.112 mM, and 1.781 mM, respectively (three replicated samples for each group, data presented as mean ± SD)