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. 2020 Jul 21;21:668. doi: 10.1186/s13063-020-04526-5

Fig. 4.

Fig. 4

Percentage of confirming the study conclusions by the different overrunning methods at the second interim analysis. The considered trial refers to the minimum number of successes to obtain the p value that crosses the O’Brien-Fleming stopping bound. Data simulated under the null (left) and alternative (right) hypotheses of the non-inferiority example