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. 2020 Jul 22;39:140. doi: 10.1186/s13046-020-01631-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Delivery of miR-375 by HUCMSC-derived exosomes repressed tumor growth of KYSE70 cells in vivo. The tumor-bearing nude mice were injected with normal saline, KYSE70 cells treated with exo-miR-375 agomir or exo-NC-agomir. A, Tumor volume in nude mice. B, Representative images of tumors in nude mice. C, HE staining of mouse tumor tissues and positive expression of ENAH, Ki-67, E-cadherin and Bcl-2 proteins in tumor tissues from nude mice detected by immunohistochemistry (scale bar = 25 μm). D, miR-375 expression and mRNA expression of ENAH, Bcl-2, Bcl-xl, Bax, CD133, Nanog and OCT-4 was determined by RT-qPCR in tumor tissues, relative to GAPDH or U6, respectively. E, Representative western blots of ENAH, E-cadherin, N-cadherin, Snail, Bcl-2, Bcl-xl, Bax, CD133, Nanog and OCT-4 proteins and their quantitation in tumor tissues, relative to GAPDH. The data are shown as mean ± standard deviation. Data in panel B-E were analyzed using one-way ANOVA and data in panel A were analyzed using repeated measures ANOVA. * p < 0.05 vs. nude mice injected with normal saline. # p < 0.05 vs. nude mice injected with KYSE70 cells treated with exo-NC-agomir. n = 10 for mice. Following each treatment