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Schematic diagram showing potential molecular mechanisms by which exosomal miR-375 regulates the progression of ESCC. miR-375 is delivered into ESCC cells via hUCMSCs-exo to decrease expression of ENAH, and subsequently to increase expression of Bax and E-cadherin but to reduce expression of N-cadherin, Snail, Bcl-2 and Bcl-xl, leading to decreased proliferation, invasion and migration and enhanced apoptosis of ESCC cells
