Expression of Kindlin-3 in Nonclassical Monocytes limits Cancer Cell Metastasis.

Left: Similar to the known effects of LFA-1 on myeloid cells, adherence of Kindlin-3-expressing Nonclassical Monocytes to the vascular endothelium activates tumor patrolling and ingestion of tumor particles, which promotes recruitment and function of NK cells and blunts extravasation of cancer cells to the metastatic area. Right: Conditional elimination of Kindlin-3 in Nonclassical Monocytes impairs their interaction with the vascular endothelium, which results in impaired tumor patrolling, reduced NK cell infiltration and promotion of tumor metastasis.