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. Author manuscript; available in PMC: 2020 Jul 22.
Published in final edited form as: J Med Chem. 2017 Jul 18;60(14):6273–6288. doi: 10.1021/acs.jmedchem.7b00584

Scheme 3. Synthesis of Target Compounds 16–39a .

Scheme 3.

aReagents and conditions: (a) RNH2, NaBH4, MeOH; (b) 2-methoxy-N-methylbenzylamine, NaBH4, MeOH; (c) 2M HCl/Et2O, rt; (d) Ph3P, DEAD, 2-fluoroethanol, THF; (e) ArCH2OTs, K2CO3, CH3CN for 24; ArCHO, NaBH(OAc)3, DCE for 33, 37-39; ArCHO, NaBH4, MeOH for 36; (f) NaOH, H2O2, MeOH.