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. Author manuscript; available in PMC: 2020 Jul 22.
Published in final edited form as: J Med Chem. 2017 Jul 18;60(14):6273–6288. doi: 10.1021/acs.jmedchem.7b00584

Scheme 5. Synthesis of Intermediates 34e-35e for Analogs 34–35a.

Scheme 5.

aReagents and conditions: (a) NBS, AIBN, CCl4, 60 oC; (b) TrtNH2, DCM, rt; (c) CH3ONa, CH3OH, CuBr, 100 oC; (d) AcOH, 50 oC.