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. 2020 Jul 21;18:91. doi: 10.1186/s12915-020-00819-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Comparison of binding modes of N12-i2 and CCR5 co-receptor to HIV-1 Env gp120. N12-i2 Fab-gp120_93TH057 core_e-M48U1 and CCR5-gp120-CD4d1d4 (PDB code 6MET) complex structures are superimposed based on gp120 outer domain. The N12-i2 Fab is displayed over the CCR5-gp120-CD4d1d4 complex (CCR5 shown as ribbon diagram and the molecular surface is displayed over gp120 and CD4). The TYS of N12-i2 and CCR5 are indicated by red arrows. The blow-up views show details of the TYS binding sites. The hydrogen bond network formed at TYS^100B of N12-i2 and Tyr¹⁵ of CCR5 is shown with dotted lines