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. 2020 Jul 21;12:110. doi: 10.1186/s13148-020-00888-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Identification of differentially methylated regions (DMRs) among the three CMT subtypes and between CMT and adjacent normal. a LMM separated CMT-DMRs (orange) and subtype-DMRs (blue green). Gray indicates none. b PCA analysis using CMT-DMRs and subtype-DMRs. CMT-DMRs successfully divides adjacent normal (green) and CMT (purple) and also subtype-DMRs into simple (orange), ductal (blue), and complex (red) types. c Genomic distribution of CMT-DMRs (up) and subtype-DMRs (down). Distribution between genic and intergenic regions (left), CGI and non-CGI (middle), and repeat and non-repeat (right). d Hyper- and hypomethylation profiles in CMT-DMRs and subtype-DMRs. Colored region (orange and blue green): hypermethylation, gray: hypomethylation