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. 2020 Jul 21;12:110. doi: 10.1186/s13148-020-00888-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Functional association of DMGs. a Hierarchical clustering of CMT-DMGs separates 11 adjacent normal (light blue) and 11 CMT (dark blue) independent of subtypes (simple, yellow; ductal, green; and complex, blue). Methylation levels were z-scored and are indicated by blue (hypo) and red (hyper) scale. b OncoScore of 224 CMT-DMGs were measured and those with a score greater than 50 are depicted. Dark blue indicates hypermethylated DMGs and downregulated in RNA-seq data and light blue indicates hypomethylated DMGs and upregulated in RNA-seq data. c Box plot shows the expression level of the top 4 orthologous genes from the TCGA database ranked by OncoScore in normal (light blue) and human invasive breast cancer (dark blue). d CMT-DMGs were clustered into the library of Disease Perturbations from GEO (down). The top 7 terms are composed of breast cancer related terms. h, human; r, rat; m, mouse; (1) breast cancer C0006142 rat GSE1872; (2) breast cancer DOID-1612 human GSE26910; (3) sporadic breast cancer DOID-8029 human GSE3744; (4) colorectal adenocarcinoma DOID-0050861 human GSE24514; (5) tendonopathy 971 human GSE26051; (6) neurological pain disorder C0423704 rat GSE15041; and (7) ductal carcinoma in situ DOID-0060074 human GSE21422. See the Table S6 to show a list of terms and p values. e Hierarchical clustering of subtype-DMGs. f GO enrichment analysis in biological process (left) and cellular component (right). Duct, ductal; Comp, complex; and Simp, simple subtype. Length of bar represents − log 10 (p value)