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Structures of sCT-bound CTR. (A) CTR ECD in complex with a sCT C-terminal fragment (PDB 5II0). (B) Full-length CTR with full-length sCT and Gs heterotrimer (PDB 6NIY). The ECD and C-terminal half of sCT were not modeled because of weak cryo-EM density for this region, apparently due to significant inter-domain flexibility.
