. Author manuscript; available in PMC: 2021 Jan 27.

Published in final edited form as: Adv Pharmacol. 2020 Jan 27;88:115–141. doi: 10.1016/bs.apha.2020.01.001

Table 1.

RAMP interactions with human class B GPCRs.

Receptor	Interacting RAMP	Modulation of	Reference(s)
CLR	RAMP1, −2, −3	Trafficking, ligand selectivity, signaling	(Hay et al., 2018; McLatchie et al., 1998; Roehrkasse et al., 2018; Weston et al., 2016)
CTR	RAMP1, −2, −3	Ligand selectivity, signaling	(Armour et al., 1999; G. Christopoulos et al., 1999; Lee et al., 2016; Morfis et al., 2008; Muff et al., 1999)
PTH1R	RAMP1^, −2, −3^	Unknown	(A. Christopoulos et al., 2003; Lorenzen et al., 2019)
PTH2R	RAMP1^, −2^, −3	Unknown	(A. Christopoulos et al., 2003; Lorenzen et al., 2019)
CRFR1	RAMP2, −3^*	Trafficking, signaling	(Bailey et al., 2019; Lorenzen et al., 2019; Wootten et al., 2013)
CRFR2	RAMP3^*	Unknown	(Lorenzen et al., 2019)
GCGR	RAMP1^, −2, −3^	Trafficking, ligand selectivity, signaling	(Cegla et al., 2017; A. Christopoulos et al., 2003; Lorenzen et al., 2019; Weston et al., 2015)
GLP1R	RAMP1^, −2^, −3^*	Unknown	(Lorenzen et al., 2019)
GLP2R	RAMP1^, −2^, −3^*	Unknown	(Lorenzen et al., 2019)
GIPR	RAMP1^, −2^, −3^*	Unknown	(Lorenzen et al., 2019)
SCTR	RAMP1^, −2^, −3	Rescue trafficking of mutant receptor	(Harikumar et al., 2009; Lorenzen et al., 2019)
GHRHR	RAMP2^, −3^	Unknown	(Lorenzen et al., 2019)
PAC1R	RAMP1^, −2^, −3^*	Unknown	(Lorenzen et al., 2019)
VPAC1R	RAMP1, −2, −3	Signaling	(A. Christopoulos et al., 2003)
VPAC2R	RAMP1, −2, −3	Signaling	(Wootten et al., 2013)

These interactions have only been observed in a high-throughput multiplexed suspension bead immunoassay using dodecylmaltoside-solubilized cells transfected with epitope tagged receptor components.