TABLE 1.

HDAC inhibition and isoform selectivity of compounds 1 and vorinostat.

Compound	IC50 (μ M)a
	HeLa nuclear extract	HDAC2	HDAC6	HDAC8
1	0.12 ± 0.01	0.33 ± 0.04	0.012 ± 0.002	3.3 ± 0.2
Vorinostat	0.25 ± 0.02	0.23 ± 0.02	0.091 ± 0.004	>5

^aAll assays were replicated (n = 3). The IC₅₀ values are shown as mean ± SD.