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In vitro antiproliferative activity of compound 1, vorinostat, and riluzole.
| Compound |
IC50 (μ M)a |
||||||
| MDA-MB-231 | MCF-7 | PC-3 | SK-N-BE(2) | KG-1 | MOLT-4 | HEL | |
| 1 | 0.77 ± 0.02 | 2.74 ± 0.06 | 2.52 ± 0.33 | 0.29 ± 0.007 | 0.65 ± 0.02 | 0.17 ± 0.007 | 0.14 ± 0.007 |
| Vorinostat | 1.58 ± 0.06 | 5.62 ± 0.06 | 9.21 ± 0.37 | 1.16 ± 0.27 | 1.59 ± 0.14 | 0.36 ± 0.049 | 0.21 ± 0.028 |
| Riluzole | >10 | NDb | >10 | NDb | >10 | NDb | >10 |
aAll assays were replicated (n = 3). The IC50 values are shown as mean ± SD. bNot determined.
