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In vitro metabolic stability of compound 1 and vorinostat.
| Compound |
t1/2 (min) |
|
| Human plasma | Human liver microsomes | |
| 1 | >120a | 56a |
| Vorinostat | 75b | 60c |
aAll assays were replicated (n ≥ 2). bData from Konsoula and Jung (2008). cData from Venkatesh et al. (2007).
