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In vivo antitumor activity in the MDA-MB-231 xenograft modela.
| Compound | TGI (%) | T/C (%) |
| 1 | 59 | 55 |
| Vorinostat | 33 | 78 |
aCompared with the control group, compound 1 showed statistically significant (p < 0.05) tumor growth inhibition (TGI) and relative increment ratio (T/C) by Student’s one-tailed t-test, and vorinostat showed no statistically significant (p > 0.05) TGI and T/C by Student’s one-tailed t-test. The TGI values are based on tumor weight.
