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. 2020 Apr 21;41(12):3266–3283. doi: 10.1002/hbm.25014

TABLE 2.

MACM coordinates for all six clusters, as well as the presence of overlap with significant rsfMRI connectivity in the cluster

Cluster size Peaks RsfMRI
Cluster 1 (right sgACC)
Large cluster including:
  • Ventromedial prefrontal cortex

  • Bilateral amygdala (LB/SF)

  • Bilateral hippocampus (CA)

  • Bilateral medial ventral striatum

  • Left caudate

3,556

12, 12, –14

−20, −6, −16

6, 38, –10

30, –14, –16

−22, −14, −14

Positive including:
  • vmFL

  • Medial VS

  • Right Amyg

  • Left HC

Right anterior insula 211 36, 18, 2 Positive
Cluster 2 (anterior medial)
Large cluster including:
  • Anterior vmFL

  • Frontal pole/dorsomedial PFC

  • Left amygdala (LB)

  • Left hippocampus (CA)

  • Bilateral ventral striatum/anterior caudate

5,188

−2, 50, –14

−20, −16, –20

10, 14, –10

−2, 40, 4

−10, 12, –6

−8, 56, 24

Positive including:
  • vmFL
  • Frontal pole
  • HC/Amyg
  • Medial VS
Precuneus/posterior cingulate 1,468

2, –52, 26

2, –44, 36

−6, −54, 10

2, –30, 46

Positive
Right hippocampus (CA)/right amygdala (LB/SF) 651

24, –6, −20

28, –18, −16

Positive
Left angular gyrus (PGp/PGa) 521

−48, −70, 28

−42, −78, 32

−50, −58, 26

Positive
Left ventrolateral PFC 396

−41, 34, –8

−42, 30, –18

−48, 26, –6

−48, 26, –12

Positive
Left middle/superior temporal gyrus 284

−58, −6, −18

−56, −2, −6

Positive
Right middle temporal gyrus (PGp/PGa) 145

50, –68, 18

50, 62, 22

Positive
Cluster 3 (central dorsal)
Large cluster including:
  • Ventromedial PFC

  • Bilateral medial ventral striatum/anterior caudate

  • Bilateral amygdala

  • Bilateral hippocampus

  • Left central OFC, anterior insula

8,617

0, 48, –6

−10, 10, –6

−24, −14, –20

26, –6, −20

12, 10, –6

10, 14, –8

Positive (all regions)
Precuneus/posterior cingulate 2,252

−2, 52, 30

4, –50, 18

Positive
Left angular/middle occipital gyrus 658

−44, −76, 32

−48, −68, 30

Positive
Left superior frontal gyrus 500 −20, 32, 46 Positive
Right anterior insula 269

38, 16, 0

46, 16, –12

48, 14, –10

Positive
Bilateral thalamus 243

−8, −14, 8

10, –16, 6

Positive
Cluster 4 (posterior)
Large cluster including:
  • Ventromedial PFC

  • Bilateral medial ventral striatum

  • Bilateral amygdala

  • Bilateral hippocampus

  • Left central OFC

  • Superior frontal gyrus

6,785

0, 30, –12

24, –2, −22

−2, 40, 2

−6, 6, –8

−2, 2, –12

14, 26, –10

Positive (all regions)
Precuneus/posterior cingulate 1,061

−4, −56, 20

−2, −52, 30

6, –52, 18

0, –36, 38

10, –56, 28

Positive
Left angular/middle temporal gyrus (PGp/PGa) 329

−48, −68, 32

−50, −66, 20

Positive
Right dorsal insula 238

38, 4, 10

42, –2, 4

Negative
Left putamen/left dorsal insula 148

−28, 4, 8

−42, −6, 8

None
Cluster 5 (central ventral)
Large cluster including:
  • Ventromedial PFC

  • Posterior frontal pole/dorsomedial PFC

  • Bilateral medial ventral striatum

  • Left amygdala

  • Left hippocampus

5,303

−2, 38, –16

−22, −14, −22

−2, 62, 4

8, 10, –10

8, 54, –8

−12, 42, 42

Positive (all regions)
Precuneus/posterior cingulate 1,009

−4, −56, 20

2, –54, 30

4, –56, 40

Positive
Right amygdala (LB/SF)/right hippocampus (CA) 540

22, –4, −20

28, –16, –20

Positive
Left central OFC/ventrolateral PFC 352

−36, 32, –16

−38, 36, –12

Positive
Left angular/middle occipital gyrus (PGp/PGa) 171

−42, −78, 30

−50, −66, 30

−44, −72, 24

Positive
Left middle temporal gyrus 121 −50, 4, –30 Positive
Cluster 6 (left sgACC)
Large cluster including:
  • Posterior ventromedial FL

  • Bilateral caudate

  • Bilateral medial VS

  • Bilateral amygdala (LB)

  • Right hippocampus

3,081

−16, 14, –14

8, 8, –12

14, 10, –14

8, 6, 2

16, –2, −2

24, –10, −20

Positive including:
  • vmFL

  • Caudate

  • VS

  • Amyg/HC

Thalamus (prefrontal/temporal‐connected region) 454

4, –18, 8

−4, −16, 6

−10, −16, 8

−10, −30, 8

None (positive but n.s.)

Abbreviations: Amyg, Amygdala; CA, cornu ammonis; HC, hippocampus; LB, laterobasal subregion; MACM, meta‐analytic connectivity modeling; OFC, orbitofrontal cortex; PFC, prefrontal cortex; rsfMRI, resting‐state fMRI; SF, superficial subregion.