Table 1.

Biology and systemic hemodynamics after 9 (D₉) and 90 d (D₉₀) imeglimin treatment

Group	Time	Lean	Zucker fa/fa
			Untreated	Imeglimin
Body Weight (g)	D9	361 ± 12	426 ± 7*	421 ± 16
	D90	415 ± 25	568 ± 11*	545 ± 13
Plasma glucose (mmol/L)	D9	4.98 ± 0.17	8.19 ± 0.47*	6.64 ± 0.39†
	D90	7.17 ± 0.61	6.73 ± 0.25	5.50 ± 0.31†
Plasma insulin (Unit/mL)	D9	‐	14.1 ± 3.5	13.3 ± 2.4
	D90	1.27 ± 0.53	4.88 ± 0.59*	4.76 ± 0.57
Plasma cholesterol (mmol/L)	D9	‐	4.11 ± 0.24	4.19 ± 0.40
	D90	2.85 ± 0.12	5.66 ± 0.23*	5.51 ± 0.33
Plasma triglycerides (mMol/L)	D9	‐	2.62 ± 0.22	1.66 ± 0.41
	D90	0.96 ± 0.12	5.02 ± 0.31*	5.24 ± 0.64
Systolic Blood Pressure (mm Hg)	D9	130 ± 6	143 ± 5	146 ± 4
	D90	108 ± 6	131 ± 6*	125 ± 5
Diastolic Blood Pressure (mm Hg)	D9	102 ± 4	101 ± 5	106 ± 2
	D90	82 ± 7	96 ± 6	90 ± 4
Heart rate (beats/min)	D9	354 ± 12	370 ± 18	381 ± 17
	D90	343 ± 9	345 ± 13	340 ± 14

^* P < .05 vs Lean zucker fa/+.

^† P < .05 vs untreated Zucker fa/fa.