Time course of SBP (a), daily sodium excretion (b) and albuminuria (c), and the data on left ventricle weights normalized by tibia length (d), in Hannover Sprague–Dawley (HanSD, transgene-negative) rats and in heterozygous Ren-2 transgenic rats (TGR), and effects of treatment with soluble epoxide hydrolase inhibitor (sEHi) or epoxyeicosatrienoic acid analogue (EET-A) given alone or combined. Values are shown as means±SEM. *P<0.05 versus basal values (or versus corresponding HanSD rats in the case of left ventricle weights). #P<0.05 versus corresponding treated TGR.