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. 2020 Jun 13;7(14):1903381. doi: 10.1002/advs.201903381

Figure 4.

Figure 4

The intracellular transport behavior of PAR‐Lipo. A) The cell internalization level of DiD labeled PAR‐Lipo and non‐Lipo. B) The intracellular behavior of DNA cargos mediated by PAR‐Lipo and non‐Lipo. C) The subcellular localization of liposomes with lysosome. D)The co‐localization of PAR‐Lipo with ER. E) The intracellular distribution of free Cy3‐DNA in cells after a pre‐incubation with the DNA, followed by the treatment with PAR‐Lipo or Non‐Lipo. F) The possible mechanism for enhanced gene editing efficiency mediated by PAR‐Lipo. PAR‐Lipo mediated CRISPR/Cas9 system to skip the lysosomes capture and deliver it into ER, inducing an increased entrance of the system into nucleus via an ER‐nucleus route. All error bars represented the ± SD.