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. Author manuscript; available in PMC: 2020 Jul 22.
Published in final edited form as: Nucl Med Biol. 2019 Nov 9;80-81:1–12. doi: 10.1016/j.nucmedbio.2019.11.002

Fig. 6.

Fig. 6.

DAB immunohistochemistry and Cy5 signal amplification with an anti-Cy5 antibody in paraffin sections of tissues from 4T1 tumor-bearing mice injected intravenously with 25 μg of either unmodified CNC, or DFO-CNC-Cy5. A HER2-positive human ductal adenocarcinoma BT-474 xenograft grown in a nu/nu mouse injected with Cy5-labeled HER2-targeting monoclonal antibody trastuzumab was used as a positive control. Magnification 10×, scale bar 100 μm. Intense DAB staining in the liver, lung, and spleen of the animal receiving DFO-CNC-Cy5 further supports the presence of Cy5-labeled CNC in these organs.