Skip to main content
. Author manuscript; available in PMC: 2020 Jul 22.
Published in final edited form as: Nucl Med Biol. 2019 Nov 9;80-81:1–12. doi: 10.1016/j.nucmedbio.2019.11.002

Fig. 7.

Fig. 7.

a) Sequestration of Cy5-labeled DFO- and NOTA-modified cellulose nanocrystals to immune cells in the mouse spleen 120 min after a single intravenous administration of 50 μg of the nanocrystals shows uptake of DFO-CNC-Cy5 to macrophages, dendritic cells (DC), Ly-6Chi monocytes (Mo) and neutrophils, with only very low numbers of Cy5-positive macrophages and Ly-6Chi monocytes detected for NOTA-CNC-Cy5. b) Negligible uptake of either DFO-CNC-Cy5 or NOTA-CNC-Cy5 is seen in the orthotopic 4T1-tdTomato tumor confirming that the nanocrystals do not reach the tumor by passive targeting. Columns denote mean ± SEM of n = 5 for DFO-CNC-Cy5 and n = 4 for NOTA-CNC-Cy5.