Table 3.
Patients characteristics at presentation
| N | Age | Sex | BMI (kg/ m2) | Charlson score | Clinic presentation | ARMC5 mutation | MENI | Serum cortisol (μg/dL) | Salivary cortisol (μg/dL) | Urinary cortisol (μg/24 h) | ACTH (pg/ mL) | Dexamethasone suppression test (μg/dL) | Adrenal volume in CT scan (cm3) | Adrenal uptake in PET/CT (SUV) | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Left | Right | Left | Right | |||||||||||||
| 1 | 53 | F | 49 | 1 | SH | – | – | 8.9 | 0.21 | 172 | <5 | 5.0 | 26.4 | 13.2 | 5.0 | 5.1 |
| 2 | 63 | F | 41 | 3 | CS | + | + | 25.9 | 0.48 | 450 | <5 | 32.8 | 54.5 | 19.2 | 8.9 | 7.1 |
| 3 | 49 | F | 27 | 2 | CS | + | – | 27.8 | 0.32 | 364 | <5 | 27.1 | 11.4 | 47.2 | 4.1 | 5.5 |
| 4 | 45 | F | 23 | 1 | CS | + | – | 18.5 | 0.65 | 389 | <5 | 18.7 | 17.4 | 38.1 | 3.4 | 2.7 |
| 5 | 45 | M | 29 | 1 | CS | + | – | 26.6 | 0.75 | 1419 | <5 | 3.9 | 220 | 67 | 4.9 | 3.3 |
| 6 | 45 | F | 31 | 1 | CS | + | – | 12.7 | 0.08 | 78 | <5 | 7.2 | 10.1 | 9.3 | 3.6 | 3.8 |
| 7 | 52 | M | 35 | 4 | CS | + | – | 26.8 | 0.85 | 100 | <5 | 25.1 | 48.6 | 41.2 | 5.6 | 5.0 |
| 8 | 50 | F | 28 | 1 | CS | – | – | 28.6 | 0.98 | 619 | <5 | 29.6 | 2 | - | 4.2 | - |
| 9 | 41 | M | 27 | 0 | SH + INC | + | – | 13.7 | 0.19 | 28 | <5 | 10.5 | 33.5 | 52.8 | 4.4 | 4.9 |
| 10 | 68 | M | 28 | 3 | SH + INC | – | – | 24.9 | 0.03 | 157 | 13.9 | 6.3 | 19.1 | 8.4 | 6.8 | 5.7 |
| 11 | 47 | F | 34 | 2 | SH + INC | – | – | 6 | 0.09 | 90 | <5 | 12.4 | 33.1 | 15.3 | 3.0 | 2.6 |
| 12 | 47 | F | 41 | 1 | SH + INC | + | – | 17 | 0.13 | 213 | <5 | 15.7 | 23 | 18.3 | 4.1 | 4.7 |
| 13 | 49 | F | 21 | 3 | SH + INC | – | + | 16 | 0.11 | 80 | 16.9 | 4.9 | 7.9 | 5 | 4.0 | 4.8 |
| 14 | 69 | F | 26 | 3 | SH + INC | – | – | 10.5 | 0.05 | 34 | 20 | 3.2 | 13.2 | 16.3 | 3.2 | 3.4 |
| 15 | 69 | F | 36 | 2 | SH + INC | + | – | 10.8 | 0.014 | 21 | <5 | 13.9 | 50.5 | 9.8 | 4.7 | 4.3 |
| 16 | 61 | M | 35 | 3 | SH + FAM | + | – | 9.1 | 0.06 | 17 | <5 | 3.7 | 9.5 | 12.6 | 2.3 | 4.1 |
| 17 | 41 | F | 48 | 0 | SH + FAM | + | – | 14.9 | 0.07 | 12 | 16.7 | 7.8 | 4.8 | 5.1 | 4.4 | 4.5 |
Reference ranges: serum cortisol = 5–25 μg/dL; midnight salivary cortisol = 0.274 μg/dL; urinary cortisol = 50–310 μg/24 hours (subjects 1-13 excluding 6); free urinary cortisol = 3.0 at 43 μg/24 hours (subjects 14-17 including 6); ACTH = 7.2–63.3 pg/mL; dexamethasone suppression test = cortisol <1.8 μg/dL.
Abbreviations: CS, Cushing’s syndrome; SH, subclinical hypercortisolism, INC, adrenal incidentaloma; MENI, meningioma; FAM, familial screening.