FIG 1.
Schematic diagram of SIV/HIV gp41 and peptide derivatives. (A) The sequence structure of gp41 and fusion inhibitor peptides. FP, fusion peptide; NHR, N-terminal heptad repeat; CHR, C-terminal heptad repeat; TM, transmembrane domain; CT, cytoplasmic tail. The positions and sequences corresponding to the T-20-resistance mutation site and the pocket-forming site in the NHR of HIV-1HXB2 reference are marked, and in which the “GIV” motif is colored blue. The pocket-binding domain (PBD) and tryptophan-rich motif in the CHR sequence are colored red and purple, respectively. C16, C18, and Chol in parentheses represent palmitic acid, stearic acid, and cholesterol, respectively; PEG8 represents a flexible linker of 8-unit polyethylene glycol. Engineered amino acids in newly designed lipopeptides are marked in pink. (B) SIVmac239 Env-derived NHR and CHR peptides. The amino acids corresponding to the characterized resistance mutations are marked in blue.