TABLE 1.
Characterization of LP-52-selected mutations in SIVmac239 Env protein
| Monkey ID | SIV env clone | gp120 mutation | gp41 mutation |
|---|---|---|---|
| M3 | m3-1 | V562M, E657G | |
| M3 | m3-2 | E283G | V562M, A836V |
| M3 | m3-3 | V562M, E657G | |
| M3 | m3-4 | V562M, E657G | |
| M3 | m3-5 | V562M, E657G | |
| M3 | m3-6 | Q359R | V562A, K631E |
| M3 | m3-7 | V562M, A836V, D851G | |
| M3 | m3-8 | V562M, E657G | |
| M3 | m3-9 | V562M, E657G | |
| M4 | m4-1 | E66G, M309I, G348K, M404I, I502V | V562M, I710V, I737T, S806T, A807V |
| M4 | m4-2 | T118P, E163G | V562M, R705K, I710V, G754R, W838R, R858K |
| M4 | m4-3 | E66G, M309I, G348K, M404I, I502V | V562M, I710V, I737T, S806T, A807V |
| M4 | m4-4 | V562A | |
| M4 | m4-5 | V562M, L802F | |
| M4 | m4-6 | V562A, A608T, N759D | |
| M4 | m4-7 | I502V | V562M, L802F, H831R |
| M5 | m5-1 | F346L | V562A, S760G |
| M5 | m5-2 | F346L | V562A, S760G |
| M5 | m5-3 | F346L | V562A, S760G, R839K |
| M5 | m5-4 | F346L | V562A, S760G |
| M5 | m5-5 | F346L | V562A, S760G |
| M5 | m5-6 | F346L | V562A, S760G |
| M5 | m5-7 | F346L | V562A, S760G |
| M5 | m5-8 | Y21S, F346L | V562A, S760G |
| M5 | m5-9 | F346L | V562A, S760G |
| M5 | m5-10 | F346L | V562A, S760G |
| M5 | m5-11 | F346L | V562A, S760G |