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Sequences of CIV PA-X genes and proteins. (A) Mutations (A→C or G→C at position 699 of the PA ORF) were introduced into the PA genes of H3N8-41X or H3N2-41X to extend the X-ORF, respectively, yielding H3N8-61X or H3N2-61X expressing full-length PA-Xs. (B) Amino acid sequence alignment of truncated or full-length PA-X from H3N8 or H3N2 CIVs. Gray indicates the different amino acids between H3N2 and H3N8 CIV PA-Xs, and the positions are marked. Asterisks represent stop codons.
