FIG 4.

NS5 maximum likelihood phylogeny of SFV in relationship to representatives of the Flavivirus genus. Classical Flavivirus subgroups are labeled according to the ICTV classification (as described in Materials and Methods); two recent subgroups containing aquatic flaviviruses are tentatively marked “Finoptera” and “Crustacean,” with purple and blue shading, respectively. The current status of viral isolation and in vivo infection, indicating the confirmation of host range and tropism, is shown for the two subgroups (filled circles, successful; open circles, not attempted or not successful). A few classical flaviviruses whose hosts were not experimentally confirmed are marked with asterisks; those whose hosts were not yet known are marked with “@.” Representatives of the genera Pegivirus, Hepacivirus, and Pestivirus within the family Flaviviridae were included in the analysis, but their taxa collapsed in final graphics. The location of NS5 in relation to the flaviviral genome is shown as a schematic.