FIG 2.

Phylogenetic analysis of ChinaGD01 and EMC/2012. (A) Phylogenetic relationship analysis and single amino acid comparison among different MERS-CoV clades based on all complete genomes available were performed. The complete genomes of 458 strains of MERS-CoV in GenBank were analyzed using the maximum-likelihood method implemented in PhyML. Numbers at the nodes represent bootstrap support. Twenty-five representative MERS-CoV genomes are highlighted with red dots (A); these were used for single amino acid difference comparison among clades (B). Corresponding amino acid mutations are presented on the right side, and the locations of amino acid substitutions are indicated.