Table 2.
Expression levels in ARPE-19 Treated cells with CPFX and TETRA compared with vehicle-treated controls
| Symbol | Treated cells with CPFX versus vehicle-control* P value, fold |
Treated cells with TETRA versus vehicle-control* P value, fold |
| Apoptosis-regulator genes | ||
| BAX | 0.002 | 0.04 |
| 1.977±0.03 | 1.465±0.09 | |
| BCL2-L13 | 0.014 | 0.026 |
| 1.41±0.02 | 1.14±0.03 | |
| BCl2 | 0.061 | 0.024 |
| 1.76±0.04 | 2.82±0.56 | |
| CASP3 | 0.246 | 0.250 |
| 1.39±0.09 | 1.25±0.30 | |
| CASP7 | 0.003 | 0.002 |
| 1.71±0.02 | 1.71±0.02 | |
| CASP9 | 0.013 | 0.007 |
| 2.13±0.19 | 1.43±0.03 | |
| Antioxidant enzymes related genes | ||
| SOD2 | 0.014 | 0.048 |
| 1.26±0.06 | 1.27±0.07 | |
| SOD3 | 0.24 | 0.041 |
| 0.80±0.05 | 0.41±0.05 | |
| NOX4 | 0.031 | 0.045 |
| 0.84±0.06 | 0.37±0.02 | |
| GPX3 | 0.018 | 0.249 |
| 1.24±0.06 | 0.69±0.01 | |
| Inflammatory pathway genes | ||
| IL-6 | 0.048 | 0.001 |
| 1.31±0.03 | 5.11±0.16 | |
| IL-1β | 0.86 | 0.023 |
| 0.31±0.05 | 2.29±0.19 | |
| IL-33 | 0.047 | 0.011 |
| 0.34±0.04 | 0.11±0.008 | |
| TGF-α1 | 0.211 | 0.014 |
| 0.67±0.06 | 0.41±0.02 | |
| TGF-β1 | 0.061 | 0.043 |
| 1.003±0.08 | 0.54±0.02 | |
| TGF-β2 | 0.410 | 0.177 |
| 0.62±0.04 | 0.74±0.07 | |
Fold values greater than 1 indicate upregulation of the gene.
Fold values less than 1 indicate downregulation of the gene.
*Are assigned a value of 1.
ARPE-19, human retinal pigment epithelial cells; CPFX, ciprofloxacin; IL-6, interleukin-6; TETRA, tetracycline; TGF-β1, transforming growth factor-β1.