Fig. 2.

Mitophagy. (A) Overview of mitophagy. An autophagosome engulfs a damaged portion of a mitochondrion to form a mitophagosome that fuses with lysosomes. The mitochondrion is degraded in the resulting mitolysosome. (B) A model showing the role of FIS1 during PINK1-mediated mitophagy. FIS1 at the damaged mitochondrial surface interacts with TBC1D15, a mitochondrial Rab GAP that inactivates RAB7A, to regulate mitophagosome formation. (C) In the absence of FIS1, the uncontrolled action of RAB7A disrupts autophagosome membrane dynamics, resulting in aberrant mitophagy.