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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: J Cancer Res Clin Oncol. 2020 May 24;146(8):2007–2016. doi: 10.1007/s00432-020-03260-4

Figure 5.

Figure 5.

Top panel shows the cytokine/chemokine profiles of culture supernatant of HER2Bi-, EGFRBi-, GD2Bi-, CD20Bi-armed CART19 cells cultured with or without their corresponding tumor targets. Data suggest dominant Th1 cytokine (Upper left panel) and chemokine profile (Upper right panel). Lower panels shows activating co-receptors expression on CD4 (Left) and CD8 T cell population (Right) of exhausted (lack of cytotoxicity), short- (24h) or long-term (2 weeks) antigen-exposed unarmed or armed CART19. Data are presented as percentage positive cells within each subset.