Skip to main content
. 2020 Jul 22;15(7):e0236115. doi: 10.1371/journal.pone.0236115

Fig 1. Rat paw withdrawal responses after injection with anti-GD2.

Fig 1

A) Rat paw withdrawal responses (allodynia, sensitivity) over the course of the study in animals drinking water without DFMO after a 1 mg/kg injection of 14G2a (p<0.001, one-way Repeated Measures ANOVA), in animals drinking water containing 0.25% and 0.5% DFMO (both p<0.005, one-way Repeated Measures ANOVA), and in animals drinking water containing 1% DFMO (p>0.05, one-way Repeated Measures ANOVA); B) The AUC after a 1 mg/kg injection of 14G2a and each DFMO concentration for the first 8h (AUC 8h) (p = 0.077, One-way ANOVA) (*p<0.05, 0% DFMO vs. 1% DFMO, post-hoc Fishers LSD test); C) Rat paw withdrawal responses in animals injected with 2 mg/kg injection of 14G2a and allowed to drink water without or with 1% DFMO (both conditions versus pre-treatment, p<0.001, one-way Repeated Measures ANOVA); D) The AUC after a 2 mg/kg injection of 14G2a for the entire 24h (AUC 24h) (^p<0.01, t-test).