Table 4.
BCFI estimates from Method II eliminating one factor at a time from the Final Modela.
| Annualized hazard rate over the first 3 years | 95% CI | 3-year BCFI event rate | 95% CI | |
|---|---|---|---|---|
| Rate assumed in the original POSITIVE design | 2.0% | 5.8% | ||
| Method I | 3.4% | (2.8%, 4.0%) | 9.5% | (7.9%, 11.1%) |
| Method II: Final Modela | 3.4% | (2.8%, 4.0%) | 9.4% | (7.8%, 10.9%) |
| Method II: eliminating age | 3.2% | (2.6%, 3.8%) | 8.9% | (7.4%, 10.5%) |
| Method II: eliminating BMI | 3.4% | (2.9%, 4.0%) | 9.5% | (8.0%, 11.1%) |
| Method II: eliminating nodal status | 3.6% | (3.0%, 4.2%) | 10.0% | (8.4%, 11.6%) |
| Method II: eliminating prior AI | 3.0% | (2.4%, 3.6%) | 8.4% | (6.9%, 9.9%) |
| Method II: eliminating prior chemotherapy | 3.5% | (2.9%, 4.1%) | 9.7% | (8.2%, 11.3%) |
a
In the final model, the matched characteristics used are age (<35, 35–39, 40–42), BMI (unknown/normal, overweight/obese), nodal status (pN0, pN+1–3, pN+4–9), prior AI received (yes, no), and prior chemotherapy received (yes, no).