Table 2.

Multivariate analysis in patients with invasive lobular carcinoma (Training Set, N = 491).

Predictors	DFS HR (95% CI) [p-value]	Replication Rate [Internal Validation]	OS HR (95% CI) [p-value]	Replication Rate [Internal Validation]
T-category according to TNM (7° Edition) [3–4 vs. 1–2]	1.78 (0.97–3.25) [0.062]	60%	–	–
Nodal Status [Positive vs. Negative]	2.46 (1.50–4.05) [<0.0001]	95%	3.32 (1.71–6.45) [<0.0001]	100%
Age [>60 years vs. ≤60 years]	–	–	2.19 (1.14–4.21) [0.019]	90%
Ki67 [≥5% vs. <5%]	–	–	2.47 (1.02–5.94) [0.044]	80%

Legend-Table 2. DFS, disease-free survival; HR, hazard ratio; CI, confidence interval; OS, overall survival, T, tumor.