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. 2020 Jul 10;16(7):e1007731. doi: 10.1371/journal.pcbi.1007731

Fig 3. Clonal family against F-RSV protein antigenic site V.

Fig 3

(A) Shown is the prefusion conformation of F-RSV trimer (PDB ID: 4MMU) [46]. The antigenic sites are colored, site Ø (red), I (blue), II (yellow), III (green), IV (purple) and V (orange). (B) Table showing the different characteristic of a mAbs clonal family isolated from an infant (≥ 6 months) after RSV infection. The Igs neutralization titers are shown as well as their related Germline annotations. ADI-14576 is highlighted because of is lower neutralization value in comparison to the other mAbs of the same clonal family. Phylogenetic analysis of the VH chain of a clonal family F-RSV specific. (C) Phylogenic tree displayed in AncesTree where the user clicked on the mutation shared by all Igs below BP3 node (31: S->N). (D) Protein alignment of the different Ig sequences, the mutation 31: S->N is boxed.