Table 2.
Risk of bias.
| Ref. | Study | Risk of bias |
Applicability concerns |
|||||
|---|---|---|---|---|---|---|---|---|
| Patient selecion | Index Test | Reference Standard | Flow and Timing∗ | Patient selecion | Index Test | Reference Standard | ||
| 26 | Brandan 2016 | H | L | L | L(0%) | H | L | L |
| 28 | Diekmann 2011 | L | L | L | H(17%) | H | L | L |
| 27 | Dromain 2011 | L | L | L | H(10%) | L | L | L |
| 29 | Lewin 2003 | U | L | L | L(1%) | L | L | L |
| 30 | Łuczyńska 2016 | H | L | L | L(0%) | H | L | L |
| 31 | Jong 2003 | L | L | L | L(5%) | H | L | L |
| 32 | Tohamey 2018 | U | H | H | L(8%) | H | H | H |
| 33 | Xing 2019 | U | L | L | L(0%) | U | L | L |
L Low risk U Unclear risk H High risk.
∗ percentage of no histology (our threshold = 5%).