Table 3.
Radiological sizes at original screen and at diagnosis and average tumour doubling times by histological type, grade, ER status and HER2 status.
| Factor | Category | N (%) | Mean (sd) diameter at screen | Mean (sd) diameter at diagnosis | Mean (95% CI) doubling time in days | Significance |
|---|---|---|---|---|---|---|
| Age | <60 years | 123 (40.2) |
13.55 (9.16) |
27.68 (14.87) |
145 (126–170) |
p = 0.01 |
| 60+ years | 183 (59.8) |
12.37 (7.15) |
25.89 (15.02) |
185 (163–213) |
||
| Grade | 1 | 35 (11.4) |
13.03 (8.64) |
21.00 (11.12) |
294 (238–385) |
p < 0.001 |
| 2 | 139 (45.4) |
12.09 (6.3) |
27.84 (16.14) |
164 (144–189) |
||
| 3 | 85 (27.8) |
12.35 (6.43) |
28.27 (13.6) |
128 (107–159) |
||
| Not known | 47 (15.4) |
15.83 (12.9) |
24.15 (15.28) |
227 (169–345) |
||
| ER status | Negative | 29 (9.5) |
13.79 (13.1) |
35.41 (21.84) |
108 (84–157) |
p < 0.001 |
| Positive | 218 (71.2) |
12.44 (6.49) |
26.24 (13.55) |
175 (158–197) |
||
| Not known | 59 (19.3) |
13.88 (9.82) |
23.66 (14.53) |
185 (140–271) |
||
| Tumour type | Ductal | 115 (37.6) |
10.9 (5.34) |
27.44 (16.22) |
138 (120–164) |
p = 0.6 |
| Lobular | 30 (9.8) |
12.57 (8.18) |
28.3 (15.98) |
154 (120–213) |
||
| Mixed/other | 17 (5.6) |
10 (4.39) |
21.59 (10.88) |
169 (126–257) |
||
| Not known | 144 (47.0) |
14.79 (9.55) |
26.19 (14.08) |
202 (172–239) |
||
| HER2 status | Negative | 197 (64.4) |
11.98 (6.48) |
26.53 (15.12) |
161 (144–182) |
p = 0.4 |
| Positive | 39 (12.7) |
14.39 (7.48) |
31.46 (13.37) |
147 (119–193) |
||
| Not known | 70 (22.9) |
14.43 (11.35) |
24.13 (14.91) |
196 (151–278) |
||
| BIRADS density | a | 14 (4.6) |
9.14 (5.36) |
31.79 (21.34) |
101 (74–156) |
p = 0.2 |
| b | 107 (35.0) |
11.92 (6.34) |
27.22 (14.02) |
158 (136–189) |
||
| c | 75 (24.5) | 13.23 (9.46) |
26.31 (14.33) |
154 (128–193) |
||
| d | 23 (7.5) | 11.87 (4.89) |
31.17 (21.38) |
165 (133–219) |
||
| Not known | 87 (28.4) |
14.51 (9.22) |
24.09 (13.12) |
219 (178–295) |
||
| All tumours | - | 306 |
12.84 (8.03) |
26.61 (14.96) |
167 (151–186) |
- |