Table 2.
Comparison of glucose level, circulating insulin concentration, insulin sensitivity, and insulin release in different groups.
| Variables | SIBO(−) (n=48) | SIBO(+) (n=56) | P |
|---|---|---|---|
| HbA1c (%) | 7.40 (6.83, 8.60) | 8.70 (7.28, 10.20)* | 0.014 |
| Glu0min (mmol/L) | 8.32±1.87 | 9.05±2.41 | 0.100 |
| Glu30min (mmol/L) | 13.66±3.02 | 14.47±3.31 | 0.214 |
| Glu60min (mmol/L) | 17.06±4.04 | 18.56±3.63 | 0.055 |
| Glu120min (mmol/L) | 18.72 (14.24,21.80) | 19.53 (17.15,22.54)* | 0.049 |
| Glu180min (mmol/L) | 13.99±5.04 | 15.78±4.33 | 0.066 |
| Ins0min (mIU/L) | 12.72 (7.72,18.53) | 8.71 (5.65,12.44)* | 0.001 |
| Ins30min (mIU/L) | 30.72 (18.42,52.96) | 17.91 (11.15,25.68)* | <0.001 |
| Ins60min (mIU/L) | 43.20 (26.74,66.16) | 24.51 (17.49,37.20)* | <0.001 |
| Ins120min (mIU/L) | 46.84 (27.37,72.79) | 30.73 (20.61,44.13)* | 0.005 |
| Ins180min (mIU/L) | 33.20 (20.78,46.51) | 23.07 (16.80,33.81)* | 0.035 |
| 1/HOMA-IR | 0.21 (0.12,0.35) | 0.30 (0.19,0.49)* | 0.015 |
| ISIM | 2.36 (1.66,3.87) | 3.55 (2.39,5.69)* | 0.006 |
| HOMA-β | 60.84 (36.61,90.53) | 35.49 (18.22,64.13)* | 0.002 |
| InsAUC30/GluAUC30 | 13.19 (8.60,24.78) | 7.51 (5.31,13.75)* | <0.001 |
| InsAUC120/GluAUC120 | 17.29 (9.54,28.76) | 9.16 (6.46,16.64)* | <0.001 |
Data are expressed as the mean ±standard deviation for variables with normal distribution or as the median and interquartile range (25th–75th percentiles) for variables without a normal distribution.
*P<0.05 vs. SIBO negative group
InsAUC30/GluAUC30 = (insulin at 0 minutes + insulin at 30 minutes of an OGTT)/(glucose at 0 minutes + glucose at 30 minutes of an OGTT).
InsAUC120/GluAUC120 = (insulin at 0 minutes + 2 × insulin at 30 minutes + 3 × insulin at 60 minutes + 2 × insulin at 120 minutes of an OGTT)/(glucose at 0 minutes + 2 × glucose at 30 minutes + 3 × glucose at 60 minutes + 2 × glucose at 120 minutes of an OGTT).
SIBO, small intestinal bacterial overgrowth; 1/HOMA-IR, 1/homeostasis model assessment of insulin resistance; ISIM, Matsuda insulin sensitivity index; OGTT, oral glucose tolerance test; Glu, glucose; Ins, insulin.