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Enhanced lesion formation by ΔfakA mutant is dependent on Hla. Mice were subcutaneously infected with 1 × 107 to 3 × 107 CFU of WT, ΔfakA, hla, or hla ΔfakA mutant S. aureus. Total lesion (A) and ulcer (B) areas were measured daily. (C) Numbers of CFU were measured on day 4 p.i. (D) Representative infection site images taken on day 4 p.i. *, P < 0.05; **, P < 0.01 by Mann-Whitney test. Data shown in panels A and B are means ± SEM (n = 6). Bars in panel C indicate the medians.
