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. 2020 Jul 21;9:e55632. doi: 10.7554/eLife.55632

Appendix 1—figure 2. Supercritical Hopf Onset DC-coupled recordings (green, top) do not have a DC shift at onset.

Appendix 1—figure 2.

The ISI is arbitrary at onset, then after 10 s starts to decrease (middle). This irregular spiking prior to the seizure (*) is not part of a clear seizure onset, does not conform to any initial bifurcation, and thus was not chosen as the unequivocal seizure onset. The sustained spiking that begins at 8 s, however, follows the SupH dynamics very well. Amplitude shows steady increase in linear scale, which appears as a straight light in loglog plots, consistent with a square root power law (loglog plot). This seizure is most consistent with SupH due to the amplitude scaling. Onset Classification: This onset is somewhat challenging because there was some disagreement about when the seizure started. A more straightforward SupH onset is seen in Figure 2 and Appendix 1—figure 8. In this case, two reviewers felt the irregular spiking was not a sustained start of the seizure and potentially was just preictal. One reviewer thought it could be the start and the seizure might be an arbitrary pattern (SubH or SN (-DC)). After discussion, reviewers agreed that the primary sustained pattern was increasing amplitude. Final analysis—DC shift: no. Amplitude increasing: yes, therefore SupH onset, but with note made of irregular spiking at seizure onset of uncertain significance. Offset Classification: This offset is difficult because there is decreasing amplitude like the onset, but then a persistent low voltage fast activity. DC shift: no. Amplitude decreasing: There was disagreement about whether the decrease comprised the final dynamotype of the seizure terminus, or if the low voltage fast activity that persisted at the end was a separate pattern. ISI increasing: no. Thus there was disagreement about whether this should be a SupH or FLC: there is a decreasing amplitude similar to the SupH onset pattern, followed by 15 s of constant ISI low voltage spiking.