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. 2020 Jul 21;9:e55632. doi: 10.7554/eLife.55632

Appendix 1—figure 9. Fold Limit Cycle offset. The primary feature of the FLC is the lack of scaling laws.

Appendix 1—figure 9.

In this case, the ISI is constant until 8 s prior to the termination, then begins to increase until 6.5 s, then decreases until 2 s, then increases again. Even if including the one low-amplitude ‘failed’ spike at the *, the ISI is still arbitrary and does not follow log or square root scaling laws (#- location of ISI if the extra spike is included). The end of the seizure is abrupt. This arbitrary pattern is consistent with FLC offset. Other examples of FLC-terminal seizures are shown in Appendix 1—figures 3, 6, 10, 17. Offset Classification: DC shift: no. Amplitude decreasing: no. ISI increasing: no (not consistent). Thus, this is a FLC offset. Onset Classification: No consensus, as it had ambiguous onset time. If it started early it could be a SN(-DC) or SubH, or if it started later it could be a SupH.