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. 2020 Jul 21;9:e55632. doi: 10.7554/eLife.55632

Figure 2. Seizure dynamics taxonomy.

Figure 2.

(A) Interspike intervals (ISI) and peak-to-peak amplitude were measured for every spike during seizures. DC shift was defined as sharp (<0.5 s) deflections that rise >5 times the background variance and persist for at least 1 s. (B) DC-coupled (red) and high-pass filtered (black) data of a seizure shows SupH onset and SH offset. (C) SN onset characterized by DC shift at onset. Ambiguous seizure offsets were included in the analysis as FLC. (D) SupH onset and offset. Although this patient did not have DC-coupled recordings, the amplitude scaling is clearly most consistent with SupH. Scale bars: 10 s. (E) Final results for all onset and offset bifurcations tested. All four bifurcation types were present. (F) Final taxonomy of the 39 patients with onset+offset classifications. In patients with DC recordings, SH offset was sometimes distinguishable from SNIC.