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. 2020 Jul 22;6(30):eaba3688. doi: 10.1126/sciadv.aba3688

Fig. 6. Cellular sensing of extracellular purine nucleosides triggers an innate immune response.

Fig. 6

Loss of extracellular ADA2 activity or an excess of extracellular purine nucleosides drives uptake of dAdo and intracellular catabolism by ADA1, yielding dIno, an immune-metabolite that directly inhibits MAT activity, the methionine cycle, and DNA methylation. Genomic hypomethylation drives up-regulation of ERV, dsRNA molecules that engage cytosolic dsRNA sensors RIG-I and MDA5 via the signaling adaptor MAVS.