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. Author manuscript; available in PMC: 2020 Oct 21.
Published in final edited form as: Chem Soc Rev. 2020 Jun 8;49(14):4906–4925. doi: 10.1039/c9cs00740g

Fig. 6.

Fig. 6

Active site of nonheme TyrH and the demonstrated reactions. (A) Crystal structure of nonheme TyrH in complex with BH4. Phe300 is self-hydroxylated to 3-OH-Phe300. PDB entry: 2TOH. (B) Natural hydroxylation of tyrosine. (C) Defluorination of 3-fluorotyrosine. (D) Dehalogenation of 4-halo-phenylalanine. 4-Fluorophenylalanine (X = F) only yields one product, namely, tyrosine. Other halogen substitutions (X = Cl, Br) afford multiple products.