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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Mov Disord. 2020 Mar 27;35(7):1253–1257. doi: 10.1002/mds.28038

TABLE 2.

Multivariate regression model results for associations between PSP features and statin use (model with 284 PSP cases), age at first statin use, and duration of statin use (model with 59 statin user PSP cases)

Statin parameters PSP risk,1 odds ratio (95% CI) Age at symptom onset,2 B (95% CI) PSP Rating Scale,3 B (95% CI) UPDRS-Total,4 B (95% CI) UPDRS-Part III,4 B (95% CI) Dementia Rating Scale,5 B (95% CI) Neuropsychiatric Inventory,4 B (95% CI)
Statin use 0.65 (0.43–1.00), P = 0.050 1.00 (0.31–1.70), P = 0.005 −3.80 (−7.03 to −0.56), P = 0.022 −7.16 (−12.17 to −2.14), P = 0.005 −4.48 (−7.89 to −1.06), P = 0.010 1.43 (−1.64 to 4.50), P = 0.36 0.55 (−2.42 to 3.53), P = 0.71
Type 1 statin use 0.60 (0.35–1.03), P = 0.064 1.09 (0.18–1.99), P = 0.049 −1.47 (−5.69 to 2.76), P = 0.50 −5.61 (−12.14 to 0.92), P = 0.092 −3.10 (−7.55 to 1.35), P = 0.17 −0.16, (−4.11 to 3.80), P = 0.94 1.82 (−1.99 to 5.63), P = 0.35
Type 2 statin use 0.81 (0.47–1.37), P = 0.43 0.61 (0.003–0.03), P = 0.17 −4.87 (−8.95 to −0.80), P = 0.019 −6.83 (−13.18 to −0.48), P = 0.035 −4.66 (−8.98 to −0.35), P = 0.034 2.34 (−1.55 to 6.23), P = 0.24 0.56 (−3.13 to 4.25), P = 0.77
Age at first statin use 0.84 (0.67–1.05), P = 0.12 0.06 (−0.003 to 0.13), P = 0.061 0.03 (−0.31 to 0.36), P = 0.88 −0.19 (−0.69 to 0.30), P = 0.44 −0.11 (−0.54 to 0.32), P = 0.61 −0.04 (−0.42 to 0.34), P = 0.84 −0.03 (−0.49 to 0.43), P = 0.90
Duration of statin use 1.04 (0.88–1.22), P = 0.67 −0.02 (−0.10 to 0.06), P = 0.59 0.13 (−0.35 to 0.60), P = 0.59 0.61 (−0.08 to 1.30), P = 0.083 0.36 (−0.12 to 0.85), P = 0.14 −0.12 (−0.55 to 0.32), P = 0.59 0.01 (−0.55 to 0.57), P = 0.97

Bold indicates statistical significance. B values show the amount of increase in outcome measure with statin use (overall, types 1 and 2), and 1-year increase in age at first statin use or duration of statin use.

1

Confounding variables in the model: years of education, smoking, pack-years, years of drinking well water.

2

Confounding variables in the model: age, smoking, pack-years.

3

Confounding variable in the model: ethnicity.

4

Confounding variables in the model: age, years of education.

5

Confounding variables in the model: age, sex, years of education, years of drinking well water.

PSP, progressive supranuclear palsy; CI, confidence interval; B, unstandardized beta coefficient; UPDRS, Unified Parkinson’s Disease Rating Scale.